Cancer therapy with TCR-engineered T cells: current strategies, challenges, and prospects
To redirect T cells against tumor cells, T cells can be engineered ex vivo to express cancer-
antigen specific T cell receptors (TCRs), generating products known as TCR-engineered T …
antigen specific T cell receptors (TCRs), generating products known as TCR-engineered T …
Structural understanding of T cell receptor triggering
X Xu, H Li, C Xu - Cellular & Molecular Immunology, 2020 - nature.com
The T cell receptor (TCR) is one of the most complicated receptors in mammalian cells, and
its triggering mechanism remains mysterious. As an octamer complex, TCR comprises an …
its triggering mechanism remains mysterious. As an octamer complex, TCR comprises an …
CD45 pre-exclusion from the tips of T cell microvilli prior to antigen recognition
The tyrosine phosphatase CD45 is a major gatekeeper for restraining T cell activation. Its
exclusion from the immunological synapse (IS) is crucial for T cell receptor (TCR) signal …
exclusion from the immunological synapse (IS) is crucial for T cell receptor (TCR) signal …
CRISPR-Cas9 cytidine and adenosine base editing of splice-sites mediates highly-efficient disruption of proteins in primary and immortalized cells
MG Kluesner, WS Lahr, C Lonetree… - Nature …, 2021 - nature.com
CRISPR-Cas9 cytidine and adenosine base editors (CBEs and ABEs) can disrupt genes
without introducing double-stranded breaks by inactivating splice sites (BE-splice) or by …
without introducing double-stranded breaks by inactivating splice sites (BE-splice) or by …
A TCR-based chimeric antigen receptor
Effector T cells equipped with engineered antigen receptors specific for cancer targets have
proven to be very efficient. Two methods have emerged: the Chimeric Antigen Receptors …
proven to be very efficient. Two methods have emerged: the Chimeric Antigen Receptors …
Allosteric activation of T cell antigen receptor signaling by quaternary structure relaxation
AL Lanz, G Masi, N Porciello, A Cohnen, D Cipria… - Cell reports, 2021 - cell.com
The mechanism of T cell antigen receptor (TCR-CD3) signaling remains elusive. Here, we
identify mutations in the transmembrane region of TCRβ or CD3ζ that augment peptide …
identify mutations in the transmembrane region of TCRβ or CD3ζ that augment peptide …
The TCR is an allosterically regulated macromolecular machinery changing its conformation while working
WW Schamel, B Alarcon, S Minguet - Immunological reviews, 2019 - Wiley Online Library
The αβ T‐cell receptor (TCR) is a multiprotein complex controlling the activation of T cells.
Although the structure of the complete TCR is not known, cumulative evidence supports that …
Although the structure of the complete TCR is not known, cumulative evidence supports that …
The T cell antigen receptor α transmembrane domain coordinates triggering through regulation of bilayer immersion and CD3 subunit associations
Initial molecular details of cellular activation following αβT cell antigen receptor (TCR)
ligation by peptide-major histocompatibility complexes (pMHC) remain unexplored. We …
ligation by peptide-major histocompatibility complexes (pMHC) remain unexplored. We …
Dual TCR T cells: identity crisis or multitaskers?
NJ Schuldt, BA Binstadt - The Journal of Immunology, 2019 - journals.aai.org
Dual TCR T cells are a common and natural product of TCR gene rearrangement and
thymocyte development. As much as one third of the T cell population may have the …
thymocyte development. As much as one third of the T cell population may have the …
Focusing on CD8+ T-cell phenotypes: improving solid tumor therapy
Z Yao, Y Zeng, C Liu, H Jin, H Wang, Y Zhang… - Journal of Experimental …, 2024 - Springer
Vigorous CD8+ T cells play a crucial role in recognizing tumor cells and combating solid
tumors. How T cells efficiently recognize and target tumor antigens, and how they maintain …
tumors. How T cells efficiently recognize and target tumor antigens, and how they maintain …