Brain tissue has a remarkable ability to accumulate glutamate. This ability is due to
glutamate transporter proteins present in the plasma membranes of both glial cells and …

Long-term potentiation and long-term depression are processes that have been widely
studied to understand the molecular basis of information storage in the brain. Glutamate …

The postsynaptic density is a highly dynamic structure, which is reorganized in an activity-
dependent manner. An animal model for temporal lobe epilepsy, ie kainate-induced limbic …

G-protein-coupled receptors (GPCRs) represent one of the largest gene families in the
animal genome. These receptors can be classified into several groups based on the …

GPCRs represent the largest family of integral membrane proteins and were first identified
as receptor proteins that couple via heterotrimeric G‐proteins to regulate a vast variety of …

Little is known about how the human brain differs from that of our closest relatives. To
investigate the genetic basis of human specializations in brain organization and cognition …

CB1 receptors are G-protein coupled receptors (GPCRs) abundant in neurons, in which they
modulate neurotransmission. The CB1 receptor influence on memory and learning is well …

In 1991 a new type of G-protein-coupled receptor (GPCR) was cloned, the type 1a
metabotropic glutamate (mGlu) receptor, which, despite possessing the defining seven …

G-protein-coupled receptors (GPCRs) transduce signals from extracellular transmitters to the
inside of the cell by activating G proteins. Mutation and overexpression of these receptors …

The Homer family of adaptor proteins consists of three members in mammals, and homologs
are also known in other animals but not elsewhere. They are predominantly localized at the …