Human RAS superfamily proteins and related GTPases

J Colicelli - Science's STKE, 2004 - science.org
The tumor oncoproteins HRAS, KRAS, and NRAS are the founding members of a larger
family of at least 35 related human proteins. Using a somewhat broader definition of …

Biological roles of translin and translin-associated factor-X: RNA metabolism comes to the fore

A Jaendling, RJ McFarlane - Biochemical Journal, 2010 - portlandpress.com
Translin, and its binding partner protein TRAX (translin-associated factor-X) are a
paralogous pair of conserved proteins, which have been implicated in a broad spectrum of …

A TB-RBP and Ter ATPase complex accompanies specific mRNAs from nuclei through the nuclear pores and into intercellular bridges in mouse male germ cells

CR Morales, S Lefrancois, V Chennathukuzhi… - Developmental …, 2002 - Elsevier
The testis brain RNA-binding protein (TB-RBP) functions as an RNA-binding protein in brain
and testis, binding to conserved sequence elements present in specific mRNAs, such as …

Mice deficient for testis-brain RNA-binding protein exhibit a coordinate loss of TRAX, reduced fertility, altered gene expression in the brain, and behavioral changes

V Chennathukuzhi, JM Stein, T Abel… - … and cellular biology, 2003 - Taylor & Francis
Testis-brain RNA-binding protein (TB-RBP), the mouse orthologue of the human protein
Translin, is a widely expressed and highly conserved protein with proposed functions in …

Testis brain ribonucleic acid-binding protein/translin possesses both single-stranded and double-stranded ribonuclease activities

J Wang, ES Boja, H Oubrahim, PB Chock - Biochemistry, 2004 - ACS Publications
RNA interference (RNAi) is a biological process in which animal and plant cells destroy
double-stranded RNA (dsRNA) and consequently the mRNA that shares sequence …

Mouse testis brain RNA-binding protein/translin selectively binds to the messenger RNA of the fibrous sheath protein glyceraldehyde 3-phosphate dehydrogenase-S …

J Yang, V Chennathukuzhi, K Miki… - Biology of …, 2003 - academic.oup.com
The testis brain RNA-binding protein (TB-RBP/translin) is a DNA-and RNA-binding protein
with multiple functions. As an RNA-binding protein, TB-RBP binds to conserved sequence …

Mapping of interaction sites of the Schizosaccharomyces pombe protein Translin with nucleic acids and proteins: a combined molecular genetics and bioinformatics …

E Eliahoo, R Ben Yosef, L Perez-Cano… - Nucleic acids …, 2010 - academic.oup.com
Translin is a single-stranded RNA-and DNA-binding protein, which has been highly
conserved in eukaryotes, from man to Schizosaccharomyces pombe. TRAX is a Translin …

Expression pattern of Drosophila translin and behavioral analyses of the mutant

K Suseendranathan, K Sengupta, R Rikhy… - European journal of cell …, 2007 - Elsevier
Translin is an evolutionarily conserved∼ 27-kDa protein that binds to specific DNA and RNA
sequences and has diverse cellular functions. Here, we report the cloning and …

Conformational transitions in human translin enable nucleic acid binding

L Perez-Cano, E Eliahoo, K Lasker… - Nucleic acids …, 2013 - academic.oup.com
Translin is a highly conserved RNA-and DNA-binding protein that plays essential roles in
eukaryotic cells. Human translin functions as an octamer, but in the octameric …

Crystal structure of TB-RBP, a novel RNA-binding and regulating protein

JM Pascal, PJ Hart, NB Hecht, JD Robertus - Journal of molecular biology, 2002 - Elsevier
The testis/brain-RNA-binding protein (TB-RBP) spatially and temporally controls the
expression of specific mRNAs in developing male germ cells and brain cells, and is …