[HTML][HTML] Nitrogen containing heterocycles as anticancer agents: a medicinal chemistry perspective
Cancer is one of the major healthcare challenges across the globe. Several anticancer
drugs are available on the market but they either lack specificity or have poor safety, severe …
drugs are available on the market but they either lack specificity or have poor safety, severe …
[HTML][HTML] Towards dual function of autophagy in breast cancer: A potent regulator of tumor progression and therapy response
M Hashemi, MDA Paskeh, S Orouei, P Abbasi… - Biomedicine & …, 2023 - Elsevier
As a devastating disease, breast cancer has been responsible for decrease in life
expectancy of females and its morbidity and mortality are high. Breast cancer is the most …
expectancy of females and its morbidity and mortality are high. Breast cancer is the most …
Topo II inhibition and DNA intercalation by new phthalazine-based derivatives as potent anticancer agents: design, synthesis, anti-proliferative, docking, and in vivo …
MM Khalifa, AA Al-Karmalawy, EB Elkaeed… - Journal of Enzyme …, 2022 - Taylor & Francis
This research presents the design and synthesis of a novel series of phthalazine derivatives
as Topo II inhibitors, DNA intercalators, and cytotoxic agents. In vitro testing of the new …
as Topo II inhibitors, DNA intercalators, and cytotoxic agents. In vitro testing of the new …
Design and synthesis of novel benzoazoninone derivatives as potential CBSIs and apoptotic inducers: in vitro, in vivo, molecular docking, molecular dynamics, and …
Apparently, tubulin inhibitors binding to the colchicine-binding site (CBS) currently have
outstanding attention for cancer treatment. So, a series of benzo [b] azonin-2-one derivatives …
outstanding attention for cancer treatment. So, a series of benzo [b] azonin-2-one derivatives …
New 1, 3, 4‐oxadiazoles linked with the 1, 2, 3‐triazole moiety as antiproliferative agents targeting the EGFR tyrosine kinase
Abstract A series of 1, 3, 4‐oxadiazole‐1, 2, 3‐triazole hybrids bearing different
pharmacophoric moieties has been designed and synthesized. Their antiproliferative activity …
pharmacophoric moieties has been designed and synthesized. Their antiproliferative activity …
[HTML][HTML] New proapoptotic chemotherapeutic agents based on the quinolone-3-carboxamide scaffold acting by VEGFR-2 inhibition
In the current study, we designed and synthesized a series of new quinoline derivatives 10a-
p as antiproliferative agents targeting cancer through inhibition of VEGFR-2. Preliminary …
p as antiproliferative agents targeting cancer through inhibition of VEGFR-2. Preliminary …
Design and synthesis of novel rigid dibenzo[b,f]azepines through ring closure technique as promising anticancer candidates against leukaemia and acting as …
MF El-Behairy, WH Abd-Allah, MM Khalifa… - Journal of Enzyme …, 2023 - Taylor & Francis
In this research, two novel series of dibenzo [b, f] azepines (14 candidates) were designed
and synthesised based on the rigidification principle and following the reported …
and synthesised based on the rigidification principle and following the reported …
[HTML][HTML] Design and synthesis of new bis (1, 2, 4-triazolo [3, 4-b][1, 3, 4] thiadiazines) and bis ((quinoxalin-2-yl) phenoxy) alkanes as anti-breast cancer agents through …
A number of new 1, ω-bis ((acetylphenoxy) acetamide) alkanes 5a–f were prepared then
their bromination using NBS furnished the novel bis (2-bromoacetyl) phenoxy) acetamides …
their bromination using NBS furnished the novel bis (2-bromoacetyl) phenoxy) acetamides …
Synthesis, characterization, and cytotoxicity of new spirooxindoles engrafted furan structural motif as a potential anticancer agent
MS Altowyan, SM Soliman, M Haukka… - ACS …, 2022 - ACS Publications
A new series of spirooxindoles based on ethylene derivatives having furan aryl moiety are
reported. The new hybrids were achieved via [3+ 2] cycloaddition reaction as an economic …
reported. The new hybrids were achieved via [3+ 2] cycloaddition reaction as an economic …
Design, synthesis, and molecular modeling studies of a novel benzimidazole as an aromatase inhibitor
In this study, a series of novel 1, 3, 4-oxadiazole-benzimidazole derivatives were designed
and synthesized. Their cytotoxic activities against five cancer cell lines, including A549, MCF …
and synthesized. Their cytotoxic activities against five cancer cell lines, including A549, MCF …