Multiple sclerosis (MS) is an inflammatory neurodegenerative disease with genetic
predisposition. Over the last decade, genome-wide association studies with increasing …

Determining effective means of preventing Multiple Sclerosis (MS) relies on testing
preventive strategies in trial populations. However, because of the low incidence of MS …

Genome-wide association studies (GWAS) successfully identified multiple sclerosis (MS)
susceptibility variants. Despite this notable progress, understanding the biological context of …

Background The pathological burden of spinocerebellar ataxia type 3, also known as
Machado–Joseph disease (SCA3/MJD), accumulates before the beginning of symptoms …

Although health-related quality of life (HRQoL) has been increasingly valued in healthcare
and in clinical trials, there is scarce information about it in spinocerebellar ataxia type …

Where sufficiently large genome-wide association study (GWAS) samples are not currently
available or feasible, methods that leverage increasing knowledge of the biological function …

Background: MS patients show abnormalities in white matter (WM) on brain imaging, with
heterogeneity in the location of WM lesions. The “pothole” method can be applied to …

Despite progress in our understanding of the earliest stages of the MS disease course,
additional research is needed to systematically identify patients with preclinical MS as well …

Background Cognitive deficits were related to Spinocerebellar Ataxia type 3/Machado-
Joseph Disease (SCA3/MJD), but the Cerebellar Cognitive Affective Syndrome (CCAS) …

Background and purpose Multiple sclerosis (MS) is associated with abnormal B‐cell
function, and MS genetic risk alleles affect multiple genes that are expressed in B cells …