Dental enamel is hardest tissue in the body and is produced by dental epithelial cells
residing in the tooth. Their cell fates are tightly controlled by transcriptional programs that are …

Dental epithelial stem cells give rise to four types of dental epithelial cells: inner enamel
epithelium (IEE), outer enamel epithelium (OEE), stratum intermedium (SI), and stellate …

There is growing evidence showing that tight junctions play an important role in developing
enamel. Claudins are one of the main components of tight junctions and may have pivotal …

Organ development is dictated by the regulation of genes preferentially expressed in tissues
or cell types. Gene expression profiling and identification of specific genes in organs can …

The extracellular matrix (ECM) is a highly dynamic amalgamation of structural and signaling
molecules whose quantitative and qualitative modifications drive the distinct programmed …

Dental enamel, the hardest tissue in the human body, is derived from dental epithelial cell
ameloblast-secreted enamel matrices. Enamel mineralization occurs in a strictly …

The development of ectodermal organs, such as teeth, requires epithelial–mesenchymal
interactions. Basic helix–loop–helix (bHLH) transcription factors regulate various aspects of …

Admixture has the potential to facilitate adaptation by providing alleles that are immediately
adaptive in a new environment or by simply increasing the long-term reservoir of genetic …

Dental enamel formation is coordinated by ameloblast differentiation, production of enamel
matrix proteins, and crystal growth. The factors regulating ameloblast differentiation are not …

Recent advances in regenerative technology have made the regeneration of various organs
using pluripotent stem cells possible. However, a simpler screening method for evaluating …