Vector-virus interactions and transmission dynamics of West Nile virus
West Nile virus (WNV; Flavivirus; Flaviviridae) is the cause of the most widespread arthropod-
borne viral disease in the world and the largest outbreak of neuroinvasive disease ever …
borne viral disease in the world and the largest outbreak of neuroinvasive disease ever …
Factors shaping the adaptive landscape for arboviruses: implications for the emergence of disease
LL Coffey, N Forrester, K Tsetsarkin… - Future …, 2013 - Taylor & Francis
Many examples of the emergence or re-emergence of infectious diseases involve the
adaptation of zoonotic viruses to new amplification hosts or to humans themselves. These …
adaptation of zoonotic viruses to new amplification hosts or to humans themselves. These …
An infectious cDNA clone of Zika virus to study viral virulence, mosquito transmission, and antiviral inhibitors
Summary The Asian lineage of Zika virus (ZIKV) has recently caused epidemics and severe
disease. Unraveling the mechanisms causing increased viral transmissibility and disease …
disease. Unraveling the mechanisms causing increased viral transmissibility and disease …
Genetic drift during systemic arbovirus infection of mosquito vectors leads to decreased relative fitness during host switching
ND Grubaugh, J Weger-Lucarelli, RA Murrieta… - Cell host & …, 2016 - cell.com
The emergence of mosquito-borne RNA viruses, such as West Nile virus (WNV), is facilitated
by genetically complex virus populations within hosts. Here, we determine whether WNV …
by genetically complex virus populations within hosts. Here, we determine whether WNV …
Host alternation of chikungunya virus increases fitness while restricting population diversity and adaptability to novel selective pressures
LL Coffey, M Vignuzzi - Journal of virology, 2011 - Am Soc Microbiol
The mechanisms by which RNA arboviruses, including chikungunya virus (CHIKV), evolve
and maintain the ability to infect vertebrate and invertebrate hosts are poorly understood. To …
and maintain the ability to infect vertebrate and invertebrate hosts are poorly understood. To …
Viral fitness: definitions, measurement, and current insights
AR Wargo, G Kurath - Current opinion in virology, 2012 - Elsevier
Viral fitness is an active area of research, with recent work involving an expanded number of
human, non-human vertebrate, invertebrate, plant, and bacterial viruses. Many publications …
human, non-human vertebrate, invertebrate, plant, and bacterial viruses. Many publications …
Insights into arbovirus evolution and adaptation from experimental studies
Arthropod-borne viruses (arboviruses) are maintained in nature by cycling between
vertebrate hosts and haematophagous invertebrate vectors. These viruses are responsible …
vertebrate hosts and haematophagous invertebrate vectors. These viruses are responsible …
Mosquitoes transmit unique West Nile virus populations during each feeding episode
Summary Arthropod-borne viruses (arboviruses), such as Zika virus, chikungunya virus, and
West Nile virus (WNV), pose continuous threats to emerge and cause large epidemics …
West Nile virus (WNV), pose continuous threats to emerge and cause large epidemics …
West Nile Virus Experimental Evolution in vivo and the Trade-off Hypothesis
ER Deardorff, KA Fitzpatrick, GVS Jerzak, PY Shi… - PLoS …, 2011 - journals.plos.org
In nature, arthropod-borne viruses (arboviruses) perpetuate through alternating replication
in vertebrate and invertebrate hosts. The trade-off hypothesis proposes that these viruses …
in vertebrate and invertebrate hosts. The trade-off hypothesis proposes that these viruses …
Tracking dengue virus intra-host genetic diversity during human-to-mosquito transmission
Dengue virus (DENV) infection of an individual human or mosquito host produces a dynamic
population of closely-related sequences. This intra-host genetic diversity is thought to offer …
population of closely-related sequences. This intra-host genetic diversity is thought to offer …