Understanding the determinants of broadly neutralizing antibody (bNAb) evolution is crucial
for the development of bNAb-based HIV vaccines. Despite emerging information on …

Pathogen strains may differ in virulence because they attain different loads in their hosts, or
because they induce different disease-causing mechanisms independent of their load. In …

Human immunodeficiency virus type 1 (HIV-1) infection is treated with antiretroviral therapy
(ART), usually consisting of 2–3 different drugs, referred to as combination ART (cART). Our …

Pathogen traits, such as the virulence of an infection, can vary significantly between patients.
A major challenge is to measure the extent to which genetic differences between infecting …

Age-mixing patterns are of key importance for understanding the dynamics of human
immunodeficiency virus (HIV)-epidemics and target public health interventions. We use the …

HIV-1 transmission precipitates a stringent genetic bottleneck, with 75% of new infections
initiated by a single genetic variant. Where multiple variants initiate infection, recipient set …

Given the urgency of rising sea levels and the need to sustain food production, developing
flood-tolerant crops is essential. The aim of this study was to assess the genetic potential of …

Background HIV-1 replication capacity (RC) of transmitted/founder viruses may influence the
further course of HIV-1 infection. Methods RCs of 355 whole-genome primary HIV-1 isolates …

Background Understanding the genetic interplay between human hosts and infectious
pathogens is crucial for how we interpret virulence factors. Here, we tested for associations …

The HIV-1 reservoir is the major hurdle to curing HIV-1. However, the impact of the viral
genome on the HIV-1 reservoir, ie its heritability, remains unknown. We investigate the …