Dysregulated lipid metabolism represents an important metabolic alteration in cancer. Fatty
acids, cholesterol, and phospholipid are the three most prevalent lipids that act as energy …

The phospholipase A2 (PLA2) superfamily contains more than 50 enzymes in mammals that
are subdivided into several distinct families on a structural and biochemical basis. In …

Objective Programmed death 1 and its ligand 1 (PD-1/PD-L1) immunotherapy is promising
for late-stage lung cancer treatment, however, the response rate needs to be improved. Gut …

While gut microbiome and host gene regulation independently contribute to gastrointestinal
disorders, it is unclear how the two may interact to influence host pathophysiology. Here we …

The small intestinal epithelium self-renews every four or five days. Intestinal stem cells
(Lgr5+ crypt base columnar cells (CBCs)) sustain this renewal and reside between …

Adequate availability of cellular building blocks, including lipids, is a prerequisite for cellular
proliferation, but excess dietary lipids are linked to increased cancer risk. Despite these …

IBD syndromes such as Crohn's disease and ulcerative colitis result from the inflammation of
specific intestinal segments. Although many studies have reported on the regenerative …

Lipid droplets are fat storage organelles present in most eukaryotic cells. They consist of a
neutral lipid core containing mostly triglycerides and sterol esters and covered by a …

The gastrointestinal tract is a multi-organ system crucial for efficient nutrient uptake and
barrier immunity. Advances in genomics and a surge in gastrointestinal diseases, has …

Differential WNT and Notch signaling regulates differentiation of Lgr5+ crypt-based
columnar cells (CBCs) into intestinal cell lineages. Recently we showed that mitochondrial …