The widely-cited model of maintenance of DNA methylation at CpG sites implies that DNA
methylation is introduced by the Dnmt3 de novo DNA methyltransferases during early …

Our current view of DNA methylation processes is strongly moving: First, even if it was
generally admitted that DNMT3A and DNMT3B are associated with de novo methylation and …

DNA methylation plays a critical role during development, particularly in repressing
retrotransposons. The mammalian methylation landscape is dependent on the combined …

DNA methylation plays an important role in epigenetic signalling, having an impact on gene
regulation, chromatin structure, development and disease. Here, we review the structures …

Genes constitute only a small proportion of the total mammalian genome, and the precise
control of their expression in the presence of an overwhelming background of noncoding …

Abstract DNA methyltransferase (cytosine-5) 1 (Dnmt1) is the principal enzyme responsible
for maintenance of CpG methylation and is essential for the regulation of gene expression …

Mouse embryos acquire global DNA methylation of their genome during implantation.
However the exact roles of DNA methyltransferases (DNMTs) in embryos have not been …

Bioinformatic analysis can not only accelerate drug target identification and drug candidate
screening and refinement, but also facilitate characterization of side effects and predict drug …

In the cell, Dnmt1 is the major enzyme in maintenance of the pattern of DNA methylation
after DNA replication. Evidence suggests that the protein is located at the replication fork …

This study was designed to determine if maternal dietary methyl supplements increase DNA
methylation and methylation-dependent epigenetic phenotypes in mammalian offspring …