The practice of polypharmacology is not a new concept but the approaches which are being
adopted for administering the two or more drugs together are varied from time to time …

Cancer is a complex disease, and its treatment is a big challenge, with variable efficacy of
conventional anticancer drugs. A two-drug cocktail hybrid approach is a potential strategy in …

Cancer is one of the leading health hazards and the prominent cause of death in the world.
A number of anticancer agents are currently in clinical practice and used for treatment of …

Coumarins are fused benzene and pyrone ring systems which prompt biological
investigation to assess their potential therapeutic significance. It possesses immeasurable …

Coumarin heterocyclic derivatives: chemical synthesis and biological activity - Natural Product
Reports (RSC Publishing) DOI:10.1039/C4NP00162A Royal Society of Chemistry View PDF …

Coumarin and benzimidazole are privileged structures in medicinal chemistry and are
widely used in drug discovery and development due to their vast biological properties. The …

Coumarins are found in higher plants like Rutaceae and Umbelliferae and essential oils of
cinnamon bark, cassia leaf, and lavender oil. Coumarin compounds show different …

The properties of benzimidazole and its derivatives have been studied over more than one
hundred years. Benzimidazole derivatives are useful intermediates/subunits for the …

A Hybrid drug which comprises the incorporation of two drug pharmacophores in one single
molecule are basically designed to interact with multiple targets or to amplify its effect …

The topoisomerase enzymes play an important role in DNA metabolism, and searching for
enzyme inhibitors is an important target in the search for new anticancer drugs. Discovery of …