Galectins are a family of endogenous glycan-binding proteins that have crucial roles in a
broad range of physiological and pathological processes. As a group, these proteins use …

Chronic obstructive pulmonary disease (COPD), the frequently fatal pathology of the
respiratory tract, accounts for half a billion cases globally. COPD manifests via chronic …

Galectin (Gal)-3 is a profibrotic β-galactoside-binding lectin that plays a key role in the
pathogenesis of idiopathic pulmonary fibrosis (IPF) and IPF exacerbations. TD139 is a novel …

A new series of orally available α-d-galactopyranosides with high affinity and specificity
toward galectin-1 have been discovered. High affinity and specificity were achieved by …

Background Organ crosstalk can be defined as the complex and mutual biological
communication between distant organs mediated by signaling factors. Normally, crosstalk …

ABSTRACT VEGFA and TGF‐β are known major angiogenic and fibrogenic factors. Galectin‐
1, encoded by lectin, galactoside‐binding, soluble (LGALS) 1, has attracted growing …

Background Idiopathic pulmonary fibrosis (IPF) is a progressive, eventually fatal disease.
IPF is characterized by excessive accumulation of the extracellular matrix (ECM) in the …

Idiopathic pulmonary fibrosis (IPF) is the most common idiopathic interstitial pulmonary
disease with a median survival of 3–5 years after diagnosis. Recent evidence identifies …

Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial lung disease causing fibrotic
remodeling of the peripheral lung, leading to respiratory failure. Peripheral pulmonary …

Oral squamous cell carcinoma, the most common type of oral cancer, affects more than
275,000 people per year worldwide. Oral squamous cell carcinoma is very aggressive, as …