Plasma free fatty acids levels are increased in subjects with obesity and type 2 diabetes,
playing detrimental roles in the pathogenesis of atherosclerosis and cardiovascular …

Inadequate or excessive nutrient consumption leads to oxidative stress, which may disrupt
oxidative homeostasis, activate a cascade of molecular pathways, and alter the metabolic …

Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease in the Western
world and its incidence is increasing rapidly. NAFLD is a spectrum ranging from simple …

Fatty liver, which frequently coexists with necro-inflammatory and fibrotic changes, may
occur in the setting of nonalcoholic fatty liver disease (NAFLD) and chronic infections due to …

Nutrients are not only organic compounds fueling bioenergetics and biosynthesis, but also
key chemical signals controlling growth and metabolism. Nutrients enormously impact the …

The comorbidities related to obesity are already extensive, but as the prevalence of obesity
increases globally, so do the number of its associated conditions. The relationship between …

Saturated fatty acids (SFAs) induce hepatocyte cell death, wherein oxidative stress is
mechanistically involved. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is a master …

There is extensive evidence showing that insulin resistance (IR) is associated with chronic
low-grade inflammation. Furthermore, IR has been shown to increase the risk for …

The metabolic syndrome (MetS) is a cluster of metabolic conditions associated to abdominal
obesity, such as elevated blood pressure, impaired glucose tolerance, insulin resistance …

Insulin resistance is characterized by hyperglycaemia, dyslipidaemia and oxidative stress
prior to the development of type 2 diabetes mellitus. To date, a number of mechanisms have …