[HTML][HTML] Bile acid nuclear receptor FXR and digestive system diseases
L Ding, L Yang, Z Wang, W Huang - Acta Pharmaceutica Sinica B, 2015 - Elsevier
Bile acids (BAs) are not only digestive surfactants but also important cell signaling
molecules, which stimulate several signaling pathways to regulate some important …
molecules, which stimulate several signaling pathways to regulate some important …
Role of bile acids and bile acid receptors in metabolic regulation
The incidence of the metabolic syndrome has taken epidemic proportions in the past
decades, contributing to an increased risk of cardiovascular disease and diabetes. The …
decades, contributing to an increased risk of cardiovascular disease and diabetes. The …
Cafestol and kahweol: A review on their bioactivities and pharmacological properties
Y Ren, C Wang, J Xu, S Wang - International journal of molecular …, 2019 - mdpi.com
Cafestol and kahweol are natural diterpenes extracted from coffee beans. In addition to the
effect of raising serum lipid, in vitro and in vivo experimental results have revealed that the …
effect of raising serum lipid, in vitro and in vivo experimental results have revealed that the …
FXR signaling in the enterohepatic system
T Matsubara, F Li, FJ Gonzalez - Molecular and cellular endocrinology, 2013 - Elsevier
Enterohepatic circulation serves to capture bile acids and other steroid metabolites
produced in the liver and secreted to the intestine, for reabsorption back into the circulation …
produced in the liver and secreted to the intestine, for reabsorption back into the circulation …
Coffee consumption, health benefits and side effects: a narrative review and update for dietitians and nutritionists
Coffee is one of the most popular beverages worldwide; however, its impact on health
outcomes and adverse effects is not fully understood. The current review aims to establish …
outcomes and adverse effects is not fully understood. The current review aims to establish …
Bile acid receptors as targets for the treatment of dyslipidemia and cardiovascular disease: Thematic review series: New lipid and lipoprotein targets for the treatment …
G Porez, J Prawitt, B Gross, B Staels - Journal of lipid research, 2012 - ASBMB
Dyslipidemia is an important risk factor for cardiovascular disease (CVD) and
atherosclerosis. When dyslipidemia coincides with other metabolic disorders such as …
atherosclerosis. When dyslipidemia coincides with other metabolic disorders such as …
Deciphering the nuclear bile acid receptor FXR paradigm
S Modica, RM Gadaleta… - Nuclear receptor …, 2010 - journals.sagepub.com
Originally called retinoid X receptor interacting protein 14 (RIP14), the farnesoid X receptor
(FXR) was renamed after the ability of its rat form to bind supra-physiological concentrations …
(FXR) was renamed after the ability of its rat form to bind supra-physiological concentrations …
Role of the intestinal bile acid transporters in bile acid and drug disposition
PA Dawson - Drug transporters, 2011 - Springer
Membrane transporters expressed by the hepatocyte and enterocyte play critical roles in
maintaining the enterohepatic circulation of bile acids, an effective recycling and …
maintaining the enterohepatic circulation of bile acids, an effective recycling and …
Bile acids and their receptors
E Martinot, L Sèdes, M Baptissart, JM Lobaccaro… - Molecular aspects of …, 2017 - Elsevier
Primary bile acids are synthetized from cholesterol within the liver and then transformed by
the bacteria in the intestine to secondary bile acids. In addition to their involvement in …
the bacteria in the intestine to secondary bile acids. In addition to their involvement in …
[HTML][HTML] Natural products as modulators of the nuclear receptors and metabolic sensors LXR, FXR and RXR
V Hiebl, A Ladurner, S Latkolik, VM Dirsch - Biotechnology advances, 2018 - Elsevier
Nuclear receptors (NRs) represent attractive targets for the treatment of metabolic syndrome-
related diseases. In addition, natural products are an interesting pool of potential ligands …
related diseases. In addition, natural products are an interesting pool of potential ligands …