Bile acids (BAs) are not only digestive surfactants but also important cell signaling
molecules, which stimulate several signaling pathways to regulate some important …

The incidence of the metabolic syndrome has taken epidemic proportions in the past
decades, contributing to an increased risk of cardiovascular disease and diabetes. The …

Cafestol and kahweol are natural diterpenes extracted from coffee beans. In addition to the
effect of raising serum lipid, in vitro and in vivo experimental results have revealed that the …

Enterohepatic circulation serves to capture bile acids and other steroid metabolites
produced in the liver and secreted to the intestine, for reabsorption back into the circulation …

Coffee is one of the most popular beverages worldwide; however, its impact on health
outcomes and adverse effects is not fully understood. The current review aims to establish …

Dyslipidemia is an important risk factor for cardiovascular disease (CVD) and
atherosclerosis. When dyslipidemia coincides with other metabolic disorders such as …

Originally called retinoid X receptor interacting protein 14 (RIP14), the farnesoid X receptor
(FXR) was renamed after the ability of its rat form to bind supra-physiological concentrations …

Membrane transporters expressed by the hepatocyte and enterocyte play critical roles in
maintaining the enterohepatic circulation of bile acids, an effective recycling and …

Primary bile acids are synthetized from cholesterol within the liver and then transformed by
the bacteria in the intestine to secondary bile acids. In addition to their involvement in …

Nuclear receptors (NRs) represent attractive targets for the treatment of metabolic syndrome-
related diseases. In addition, natural products are an interesting pool of potential ligands …