The mammalian heart is responsible for not only pumping blood throughout the body but
also adjusting this pumping activity quickly depending upon sudden changes in the …

Optimal cardiac function depends on proper timing of excitation and contraction in various
regions of the heart, as well as on appropriate heart rate. This is accomplished via …

Cellular electrophysiology experiments, important for understanding cardiac arrhythmia
mechanisms, are usually performed with channels expressed in non myocytes, or with non …

Calcium ions (Ca2+) play a major role in the cardiac excitation-contraction coupling.
Intracellular Ca2+ concentration increases during systole and falls in diastole thereby …

Cardiac arrhythmias are a major cause of death and disability. A large number of
experimental cell and animal models have been developed to study arrhythmogenic …

Explanations for arrhythmia mechanisms at the cellular level are usually based on
experiments in nonhuman myocytes. However, subtle electrophysiological differences …

Local signaling domains and numerous interacting molecular pathways and substrates
contribute to the whole-cell response of myocytes during β-adrenergic stimulation (βARS) …

Computational models of cardiac myocytes are important tools for understanding ionic
mechanisms of arrhythmia. This work presents a new model of the canine epicardial …

The generation of human cardiomyocytes (CMs) from human pluripotent stem cells (hPSCs)
has become an important resource for modeling human cardiac disease and for drug …

Reentry is the main mechanism of life-threatening ventricular arrhythmias, including
ventricular fibrillation and tachycardia. Its occurrence depends on the simultaneous …