Infection or sterile inflammation triggers site-specific attraction of leukocytes. Leukocyte
recruitment is a process comprising several steps orchestrated by adhesion molecules …

Abstract αβ heterodimeric integrins mediate dynamic adhesive cell-cell and cell-extracellular
matrix (ECM) interactions in metazoa that are critical in growth and development …

The relevance of extracellular magnesium in cellular immunity remains largely unknown.
Here, we show that the co-stimulatory cell-surface molecule LFA-1 requires magnesium to …

CD47 acts as a" don't eat me" signal that protects cells from phagocytosis by binding and
activating its receptor SIPRA on macrophages. CD47 suppresses multiple different pro …

Monocytes are effectors of the inflammatory response to microbes. Human CD14+
monocytes specialize in phagocytosis and production of reactive oxygen species and …

The mucosal vascular addressin, MAdCAM-1, is an immunoglobulin superfamily adhesion
molecule for lymphocytes that is expressed by mucosal venules and helps direct lymphocyte …

Exercise benefits the human body in many ways. Irisin is secreted by muscle, increased with
exercise, and conveys physiological benefits, including improved cognition and resistance …

Although critical for development, immunity, wound healing, and metastasis, integrins
represent one of the few classes of plasma membrane receptors for which the basic …

Integrins are a family of α/β heterodimeric adhesion metalloprotein receptors and their
functions are highly dependent on and regulated by different divalent cations. Recently …

Dendritic cells (DCs) are known to secrete exosomes that transfer membrane proteins, like
major histocompatibility complex class II, to other DCs. Intercellular transfer of membrane …