In space, multiple unique environmental factors, particularly microgravity and space
radiation, pose constant threat to the DNA integrity of living organisms. Specifically, space …

Cancer genome instability arises from diverse defects in DNA-repair machinery, which make
cancer cells more susceptible to DNA targeting agents. The interrelation between DNA …

Myotonic dystrophy type 1 (DM1) is caused by a highly structured RNA repeat expansion, r
(CUG) exp, harbored in the 3′ untranslated region (3′ UTR) of dystrophia myotonica …

Bleomycin (BLM) is an antibiotic isolated from Streptomyces verticillus. It has radiomimetic
actions on DNA thus it has been widely used in clinical chemotherapy for the treatment of …

Abstract Space biotechnology is a nascent field aimed at applying tools of modern biology to
advance our goals in space exploration. These advances rely on our ability to exploit in situ …

Fungi have been companions of mankind for millennia. Mushrooms inspired our eating
culture, and yeasts and filamentous fungi were developed into highly efficient cell factories …

Spaceflight causes cardiovascular changes due to microgravity-induced redistribution of
body fluids and musculoskeletal unloading. Cardiac deconditioning and atrophy on Earth …

The International Space Station (ISS) National Laboratory is dedicated to studying the
effects of space on life and physical systems, and to developing new science and …

In this review article, we discuss the current state of knowledge in cancer research under
real and simulated microgravity conditions and point out further research directions in this …

Spaceflight alters many processes of the human body including cardiac function and cardiac
progenitor cell behavior. The mechanism behind these changes remains largely unknown; …