Oxygen deprivation (hypoxia) in non–small cell lung cancer (NSCLC) is an important factor
in treatment resistance and poor survival. Hypoxia is an attractive therapeutic target …

Multiparametric imaging is a critical tool in the noninvasive study and assessment of cancer.
Imaging methods have evolved over the past several decades to provide quantitative …

Radiotherapy (RT) as one of the most powerful cancer treatment strategies has been greatly
restricted by tumor hypoxia. A mounting effort has been devoted to develop oxygen delivery …

Purpose: Hypoxia is a common characteristic of many tumor microenvironments, and it has
been shown to promote suppression of antitumor immunity. Despite strong biological …

Simple Summary Tumor heterogeneity influences tumor progression and response to
therapy, introducing a significant challenge in the treatment of breast cancer. We employed …

This study identifies physiological tumor habitats from quantitative magnetic resonance
imaging (MRI) data and evaluates their alterations in response to therapy. Two models of …

The goal of this study is to develop an integrated, mathematical–experimental approach for
understanding the interactions between the immune system and the effects of trastuzumab …

Advancements in monitoring and predicting of patient-specific response of triple negative
breast cancer (TNBC) to immunotherapy (IMT) with and without chemotherapy are needed …

Metabolic reprogramming is not only an emerging hallmark of cancer, but also an essential
regulator of cancer cell adaptation to the microenvironment. Metabolic imaging targeting …

The purpose of this study is to investigate imaging and histology-based measurements of
intratumoral heterogeneity to evaluate early treatment response to targeted therapy in a …