Liver fibrosis is a repair process in response to damage in the liver; however, severe and
chronic injury promotes the accumulation of fibrous matrix, destroying the normal functions …

Background: The evolutionarily conserved Hedgehog (Hh) signaling cascade is one of the
key mediators of embryonic development of many metazoans. This pathway has been …

Activation of hepatic stellate cells (HSCs) contributes to the development of liver fibrosis.
Because of a relatively small population of HSCs in the liver and the lack of specific …

The management of pancreatic ductal adenocarcinoma (PDAC) is extremely poor due to
lack of an efficient therapy and development of chemoresistance to the current standard …

Hypothalamic hamartoma (HH) with gelastic epilepsy is a well-recognized drug-resistant
epilepsy syndrome of early life. 1 Surgical resection allows limited access to the small deep …

Graft-versus-host disease (GVHD) is the most common complication of hematopoietic stem
cell transplant (HCT). However, our understanding of the molecular pathways that cause this …

Breast cancer stem cells (BCSCs) are believed to be responsible for tumor
chemoresistance, recurrence, and metastasis formation. Salinomycin (SAL), a carboxylic …

Because the transcription factor activator protein-1 (AP-1) regulates a variety of protein-
encoding genes, it is a participant in many cellular functions, including proliferation …

Many patients with acute myeloid leukemia will eventually develop refractory or relapsed
disease. In the absence of standard therapy for this population, there is currently an urgent …

The dopaminergic neurons are responsible for the release of dopamine. Several diseases
that affect motor function, including Parkinson's disease (PD), are rooted in inadequate …