Cerebral cavernous malformations are acquired vascular anomalies that constitute a
common cause of central nervous system hemorrhage and stroke. The past 2 decades have …

Stroke is an important cause of neurological morbidity in children; most survivors have
permanent neurological deficits that affect the remainder of their life. Stroke in childhood, the …

Cerebral cavernous malformations (CCMs) are common inherited and sporadic vascular
malformations that cause strokes and seizures in younger individuals. CCMs arise from …

The mammalian striatin family consists of three proteins, striatin, S/G 2 nuclear autoantigen,
and zinedin. Striatin family members have no intrinsic catalytic activity, but rather function as …

At first sight, the nervous and vascular systems seem to share little in common. However,
neural and vascular cells not only are anatomically closely tied to each other, but they also …

Cerebral cavernous malformations (CCM s) are vascular malformations located within the
central nervous system often resulting in cerebral hemorrhage. Pharmacological treatment is …

Cerebral cavernous malformations (CCMs) are vascular lesions that can occur sporadically
or as a consequence of inherited loss-of-function mutations, predominantly in the genes …

Background—Cerebral cavernous malformation (CCM) is a hemorrhagic stroke disease
affecting up to 0.5% of North Americans that has no approved nonsurgical treatment. A …

Rationale: Vascular malformations arise in vessels throughout the entire body. Causative
genetic mutations have been identified for many of these diseases; however, little is known …

Somatic activating mutations of PIK3CA are associated with development of vascular
malformations (VMs). Here, we describe a microfluidic model of PIK3CA-driven VMs …