Peripheral nerve injuries that induce gaps larger than 1–2cm require bridging strategies for
repair. Autologous nerve grafts are still the gold standard for such interventions, although …

Cell alignment plays a critical role in various cell behaviors including cytoskeleton
reorganization, membrane protein relocation, nucleus gene expression, and ECM …

Sustained release of proteins from aligned polymeric fibers holds great potential in tissue‐
engineering applications. These protein–polymer composite fibers possess high surface …

Peripheral nerve injury (PNI) is a complex disease that often appears in young adults. It is
characterized by a high incidence, limited treatment options, and poor clinical outcomes …

Endogenous electric fields are instructive during embryogenesis by acting to direct cell
migration, and postnatally, they can promote axonal growth after injury (McCaig 1991, Al …

Nerve regeneration is a complex biological phenomenon. Once the nervous system is
impaired, its recovery is difficult and malfunctions in other parts of the body may occur …

When coaptation is not possible in the repair of nerve injuries, a bridge of biomaterial
scaffold provides a structural support for neuronal cell growth and guides nerve …

Accurate control over positioning of cells is a highly desirable feature in tissue engineering
applications since it allows, for example, population of substrates in a controlled fashion …

Axonal extension is influenced by a variety of external guidance cues; therefore, the
development and optimization of a multi-faceted approach is probably necessary to address …

Neuroregeneration following peripheral nerve injury is largely mediated by Schwann cells
(SC), the principal glial cell that supports neurons in the peripheral nervous system. Axonal …