Neuronal communication crucially relies on exocytosis of neurotransmitters from synaptic
vesicles (SVs) which are clustered at synapses. To ensure reliable neurotransmitter release …

Structural and functional collapse of the balance between excitatory (E) and inhibitory (I)
synapses, ie, synaptic E/I balance, underlies the pathogeneses of various central nervous …

Individuals at distinct stages of Alzheimer's disease (AD) show abnormal
electroencephalographic activity, which has been linked to network hyperexcitability and …

In presynaptic terminals, synaptic vesicles (SVs) are found in a discrete cluster that includes
a reserve pool that is mobilized during synaptic activity. Synapsins serve as a key protein for …

Synaptopathies are a class of neurodevelopmental disorders caused by modification in
genes coding for synaptic proteins. These proteins oversee the process of …

Synaptic transmission is the communication between a presynaptic and a postsynaptic
neuron, and the subsequent processing of the signal. These processes are complex and …

Endocytosis is a process essential to the health and well-being of cell. It is required for the
internalisation and sorting of “cargo”—the macromolecules, proteins, receptors and lipids of …

Several synaptic genes predisposing to autism-spectrum disorder (ASD) have been
identified. Nonsense and missense mutations in the SYN1 gene encoding for Synapsin I …

Synapsins (Syns) are phosphoproteins strongly involved in neuronal development and
neurotransmitter release. Three distinct genes SYN1, SYN2 and SYN3, with elevated …

Highlights•The use of next-generation sequencing has expanded epilepsy-related genes.•
Superresolution microscopy revealed subsynaptic distribution of synaptic …