Cholesterol is a critical component of membrane bilayers where it plays key structural and
functional roles by regulating the activity of diverse signaling platforms and pathways …

Alzheimer's disease (AD) is the most common form of dementia in older adults. Currently,
there is no cure for AD. The hallmark of AD is the accumulation of extracellular amyloid …

Malignant transformation and tumour progression are associated with cancer-cell softening.
Yet how the biomechanics of cancer cells affects T-cell-mediated cytotoxicity and thus the …

Cholesterol is a key component of all mammalian cell membranes. Disruptions in
cholesterol metabolism have been observed in the context of various diseases, including …

Cell proliferation and function require nutrients, energy, and biosynthesis activity to duplicate
repertoires for each daughter. It is therefore not surprising that tumor microenvironment …

Abnormality in cholesterol homeostasis in the brain is a feature of Alzheimer's disease (AD).
27-Hydroxycholesterol (27-OHC) has been identified as a possible biomarker of AD, but its …

Alzheimer's disease (AD) is a complex neurological ailment that causes cognitive decline
and memory loss. Cholesterol metabolism dysregulation has emerged as a crucial element …

The Retinoic acid-related orphan receptor alpha (RORα) protein first came into the limelight
due to a set of staggerer mice, discovered at the Jackson Laboratories in the United States …

Abstract Acyl-coenzymeA: cholesterol acyltransferase 2 (ACAT2) is abundantly expressed in
intestine and fetal liver of healthy human. Our previous studies have shown that in monocytic …

Cancer is one of the leading causes of death globally. Immunotherapy represents one of the
most promising cancer treatments inducing complete and durable responses in a fraction of …