Extensive research has been undertaken in the pursuit of anticancer therapeutics. Many
anticancer drugs require specificity of delivery to cancer cells, whilst sparing healthy tissue …

Gap junctions (GJ) and connexins play integral roles in cellular physiology and have been
found to be involved in multiple pathophysiological states from cancer to cardiovascular …

Neurogenesis is a key mechanism of brain development and plasticity, which is impaired in
chronic neurodegeneration, including Parkinson's disease. The accumulation of aberrant α …

Simple Summary Connexins are proteins which comprise gap junctions in cells. These
junctions can directly connect neighboring cells and the cell interior with the extracellular …

Astrocytes have emerged as major players in the brain, contributing to many functions such
as energy supply, neurotransmission, and behavior. They accomplish these functions in part …

Src, a non-receptor tyrosine kinase, was first discovered as a prototype oncogene and has
been shown to critical for cancer progression for a variety of tissues. Src activity is regulated …

Increased fatty acid synthesis benefits glioblastoma malignancy. However, the coordinated
regulation of cytosolic acetyl-CoA production, the exclusive substrate for fatty acid synthesis …

Simple Summary Glioblastoma is the product of accumulated genetic and epigenetic
alteration where tumor cells support each other through cellular communication …

Abstract Connexin 43 (Cx43) expression is decreased in the prefrontal cortex of patients
with depression, but its significance is still unknown. Neurotrophic factors, such as brain …

Neural precursor cells (NPCs) that persist in the postnatal/adult subventricular zone (SVZ)
express connexins that form hemichannels and gap junctions. Gap junctional …