Cardiovascular disease (CVD) is the leading cause of mortality in the Western world. The
effort of research should aim at the primary prevention of CVD. Alongside statin therapy …

Background: The relationship between metabolic syndrome (MetS), male hypogonadism
and their possible interaction in cardiovascular (CV) risk stratification are not completely …

Rationale: Vitamin E transport and steroidogenesis are closely associated with low-density
lipoproteins (LDLs) metabolism, and evolocumab can lower LDL cholesterol (LDL-C) to low …

Purpose: Statins are one of the most prescribed classes of drugs worldwide to treat
hypercholesterolemia and dyslipidemia. By lowering the level of cholesterol, the use of statin …

Background This represents the first update of this review, which was published in 2012.
Atorvastatin is one of the most widely prescribed drugs and the most widely prescribed statin …

Acute illness can produce dramatic changes in endocrine function. 1–3 Activation of the
hypothalamic-pituitary-adrenal (HPA) axis, as evidenced by an increase in secretion of …

Background Hyperandrogenaemia in polycystic ovary syndrome (PCOS) represents a
composite of raised serum concentrations of testosterone, androstenedione …

Background Erectile dysfunction complaints among men treated with a statin are not
uncommon. Objectives To evaluate the effect of lowering low-density lipoprotein cholesterol …

The neuroendocrine response to critical illness is key to the maintenance of homeostasis.
Many of the drugs administered routinely in the intensive care unit significantly impact the …

Background and aims Therapeutic possibilities now exist to lower low-density lipoprotein
cholesterol (LDL-C) to very low levels. However, substantial controversy remains in clinical …