Human epidermal growth factor receptor 2 (HER2), a targetable transmembrane
glycoprotein receptor of the epidermal growth factor receptor (EGFR) family, plays a crucial …

Simple Summary Breast cancer (BC) is the most common malignant neoplasm in women
and one of the leading causes of cancer death in women worldwide. Programmed death …

Despite decades of study, the molecular mechanisms and selectivity of the biomolecular
components of honeybee (Apis mellifera) venom as anticancer agents remain largely …

Gastric cancer is one of the most lethal human malignancies in the world. Although great
efforts are put in developing novel therapeutic targets, the effective targeting drugs are still …

In this multi-center phase II trial, we evaluated the efficacy and safety of a quadruplet
regimen (pembrolizumab, trastuzumab, and doublet chemotherapy) as first-line therapy for …

New strategies for cancer immunotherapy are needed since most solid tumors do not
respond to current approaches. Here we used epithelial cell adhesion molecule EpCAM (a …

Immune checkpoint blockade has shown significant clinical benefit in multiple cancer
indications, but many patients are either refractory or become resistant to the treatment over …

Simple Summary Breast cancer is one of the most common health problems in the world. As
a result, governments and researchers in different countries are trying to help prevent the …

Simple Summary The aim of our study is to provide a wide perspective on the available
literature data on the immune landscape of breast cancers, focusing on TILs and PD-L1 …

Maintaining the balance between eliciting immune responses against foreign proteins and
tolerating self-proteins is crucial for maintenance of homeostasis. The functions of …