Pax genes play key roles in the formation of tissues and organs during embryogenesis.
Pax3 and Pax7 mark myogenic progenitor cells and regulate their behavior and their entry …

Pax6 is a highly conserved transcription factor among vertebrates and is important in various
developmental processes in the central nervous system (CNS), including patterning of the …

The aryl hydrocarbon receptor (AhR) participates in the differentiation of mouse regulatory T
cells (Treg cells) and interleukin 17 (IL-17)-producing helper T cells (TH17 cells), but its role …

During development of the anterior eye segment, cells that originate from the surface
epithelium or the neuroepithelium need to interact with mesenchymal cells, which …

Insulin gene expression is regulated by several islet-enriched transcription factors. However,
MafA is the only β cell-specific activator. Here, we show that MafA selectively induces …

The specialized endocrine and exocrine cells of the pancreas originally derive from a pool of
apparently identical cells in the early gut endoderm. Serial changes in their gene expression …

Major insulin gene transcription factors, such as PDX-1 or NeuroD1, have equally important
roles in pancreatic development and the differentiation of pancreatic endocrine cells …

The insulin gene is specifically expressed in β-cells of the Langerhans islets of the
pancreas, and its transcription is regulated by the circulating glucose level. Previous reports …

Abstract The C1/RIPE3b1 (− 118/− 107 bp) binding factor regulates pancreatic-β-cell-
specific and glucose-regulated transcription of the insulin gene. In the present study, the …

PAX6 function was first identified through aniridia-associated null mutations. Since then, this
transcription factor, with a paired domain and a homeodomain, has become a paradigm …