Although islet transplantation has demonstrated its potential use in treating type 1 diabetes,
this remains limited by the need for daily immunosuppression. Islet encapsulation was then …

Low oxygenation of islets contributes to cellular death and dysfunction during preparation of
islets for transplantation, as well as posttransplantation. Interventions at these different steps …

Transplantation of pancreatic islets or stem cell derived insulin secreting cells is an attractive
treatment strategy for diabetes. However, islet transplantation is associated with several …

Islet isolation and purification using a continuous density gradient may reduce the volume of
tissue necessary for implantation into patients, therefore minimizing the risks associated with …

Pancreatic islet transplantation is a promising alternative to whole‐pancreas transplantation
as a treatment of type 1 diabetes mellitus. This technique has been extensively developed …

Pancreatic islet transplantation into the liver provides a possibility to treat selected patients
with brittle type 1 diabetes mellitus. However, massive early β-cell death increases the …

We evaluated the effect of resveratrol (RSV) on graft survival after islet transplantation (ITx)
in diabetic mice. Isolated islets from Balb/c mice (200 IEQ) were transplanted under the …

The conversion of differentiated cells into insulin-producing cells is a promising approach for
the autologous replacement of pancreatic cells in patients with type 1 diabetes (T1D). At …

For gene transfer strategies to improve islet engraftment, vascular endothelial growth factor
(VEGF) expression should be regulated in a way that matches the transient nature of …

Insulin-producing cells derived from human embryonic stem cells (hESCs) or induced
pluripotent stem cells (iPSCs) have for long been a promising, but elusive treatment far from …