Common mechanisms of excitatory and inhibitory imbalance in schizophrenia and autism spectrum disorders
R Gao, P Penzes - Current molecular medicine, 2015 - ingentaconnect.com
Autism Spectrum Disorders (ASD) and Schizophrenia (SCZ) are cognitive disorders with
complex genetic architectures but overlapping behavioral phenotypes, which suggests …
complex genetic architectures but overlapping behavioral phenotypes, which suggests …
Interneuron dysfunction in psychiatric disorders
O Marín - Nature Reviews Neuroscience, 2012 - nature.com
Schizophrenia, autism and intellectual disabilities are best understood as spectrums of
diseases that have broad sets of causes. However, it is becoming evident that these …
diseases that have broad sets of causes. However, it is becoming evident that these …
Oxidative stress-driven parvalbumin interneuron impairment as a common mechanism in models of schizophrenia
P Steullet, JH Cabungcal, J Coyle, M Didriksen… - Molecular …, 2017 - nature.com
Parvalbumin inhibitory interneurons (PVIs) are crucial for maintaining proper
excitatory/inhibitory balance and high-frequency neuronal synchronization. Their activity …
excitatory/inhibitory balance and high-frequency neuronal synchronization. Their activity …
[图书][B] Neuro: The new brain sciences and the management of the mind
N Rose, JM Abi-Rached - 2013 - degruyter.com
The brain sciences are influencing our understanding of human behavior as never before,
from neuropsychiatry and neuroeconomics to neurotheology and neuroaesthetics. Many …
from neuropsychiatry and neuroeconomics to neurotheology and neuroaesthetics. Many …
Oxidative stress and psychological disorders
S Salim - Current neuropharmacology, 2014 - ingentaconnect.com
Oxidative stress is an imbalance between cellular production of reactive oxygen species and
the counteracting antioxidant mechanisms. The brain with its high oxygen consumption and …
the counteracting antioxidant mechanisms. The brain with its high oxygen consumption and …
An overview of animal models related to schizophrenia
Schizophrenia is a heterogeneous psychiatric disorder that is poorly treated with current
therapies. In this brief review, we provide an update regarding the use of animal models to …
therapies. In this brief review, we provide an update regarding the use of animal models to …
Animal models of schizophrenia
CA Jones, DJG Watson… - British journal of …, 2011 - Wiley Online Library
Developing reliable, predictive animal models for complex psychiatric disorders, such as
schizophrenia, is essential to increase our understanding of the neurobiological basis of the …
schizophrenia, is essential to increase our understanding of the neurobiological basis of the …
Linking early-life NMDAR hypofunction and oxidative stress in schizophrenia pathogenesis
GE Hardingham, KQ Do - Nature Reviews Neuroscience, 2016 - nature.com
Molecular, genetic and pathological evidence suggests that deficits in GABAergic
parvalbumin-positive interneurons contribute to schizophrenia pathophysiology through …
parvalbumin-positive interneurons contribute to schizophrenia pathophysiology through …
Linking mPFC circuit maturation to the developmental regulation of emotional memory and cognitive flexibility
CB Klune, B Jin, LA DeNardo - Elife, 2021 - elifesciences.org
The medial prefrontal cortex (mPFC) and its abundant connections with other brain regions
play key roles in memory, cognition, decision making, social behaviors, and mood …
play key roles in memory, cognition, decision making, social behaviors, and mood …
The neuropsychopharmacology of fronto-executive function: monoaminergic modulation
TW Robbins, AFT Arnsten - Annual review of neuroscience, 2009 - annualreviews.org
We review the modulatory effects of the catecholamine neurotransmitters noradrenaline and
dopamine on prefrontal cortical function. The effects of pharmacologic manipulations of …
dopamine on prefrontal cortical function. The effects of pharmacologic manipulations of …