Small populations of adult stem cells are responsible for the remarkable ability of the
epithelial lining of the intestine to be efficiently renewed and repaired throughout life. The …

The evolutionarily conserved Wnt signaling pathway plays essential roles during embryonic
development and tissue homeostasis. Notably, comprehensive genetic studies in …

The canonical Wnt/β-catenin signalling pathway governs diverse developmental,
homeostatic and pathological processes. Palmitoylated Wnt ligands engage cell-surface …

Luteinizing hormone and chorionic gonadotropin are glycoprotein hormones that are related
to follicle-stimulating hormone and thyroid-stimulating hormone,. Luteinizing hormone and …

Lgr5 was originally discovered as a common Wnt target gene in adult intestinal crypts and
colon cancer. It was subsequently identified as an exquisite marker of multiple Wnt-driven …

Renewal of the intestinal epithelium occurs approximately every week and requires a careful
balance between cell proliferation and differentiation to maintain proper lineage ratios and …

The four R-spondin secreted ligands (RSPO1–RSPO4) act via their cognate LGR4, LGR5
and LGR6 receptors to amplify WNT signalling,–. Here we report an allelic series of …

Obesity has become epidemic worldwide, which triggers several obesity-associated
complications. Obesity is characterized by excess fat storage mainly in the visceral white …

Rapidly renewing tissues such as the intestinal epithelium critically depend on the activity of
small-sized stem cell populations that continuously generate new progeny to replace lost …

The WNT signaling pathway regulates patterning and morphogenesis during development
and promotes tissue renewal and regeneration in adults. The R-spondin (RSPO) family of …