AIM Probably, the most important and potentially lethal adverse event of azathioprine (AZA)
and mercaptopurine (MP) is myelosuppression. Our aim was to conduct a review of AZA/MP …

Aliment Pharmacol Ther 2012; 35: 15–36 Summary Background Thiopurines represent an
effective and widely prescribed therapy in inflammatory bowel disease (IBD). Concerns …

Glutathione transferase enzymes (GSTs) catalyze reactions in which electrophiles are
conjugated to the tripeptide thiol glutathione. While many GST-catalyzed transformations …

Background Azathioprine and mercaptopurine have a pivotal role in the treatment of
inflammatory bowel disease (IBD). However, because of their complex metabolism and …

Inflammatory bowel diseases (IBDs), including ulcerative colitis and Crohn's disease, affect
several million individuals worldwide. These diseases are heterogeneous at the clinical …

Background: The evidence for testing thiopurine S-methyltransferase (TPMT) enzymatic
activity or genotype before starting therapy with thiopurine-based drugs is unclear. Purpose …

Thiopurine S-methyltransferase (TPMT) metabolizes thiopurine medications, including
azathioprine and 6-mercaptopurine. Absent TPMT activity (ie, in individuals homozygous for …

Background Thiopurine‐induced leukopenia, a frequently observed and potentially life‐
threatening adverse event, complicates the clinical management of IBD patients. Aim To …

Azathioprine is a purine antimetabolite drug commonly used to treat inflammatory bowel
disease (IBD). In vivo it is active after reaction with reduced glutathione (GSH) and …

Background Azathioprine (AZA) pharmacogenetics are complex and much studied. Genetic
polymorphism in TPMT is known to influence treatment outcome. Xanthine oxidase …