Tumour-associated macrophages are an essential component of the tumour
microenvironment and have a role in the orchestration of angiogenesis, extracellular matrix …

Triple-negative breast cancer (TNBC) encompasses a heterogeneous group of
fundamentally different diseases with different histologic, genomic, and immunologic …

Neutrophils accumulate in solid tumors, and their abundance correlates with poor prognosis.
Neutrophils are not homogeneous, however, and could play different roles in cancer …

Neutrophils are the most abundant myeloid cells in human blood and are emerging as
important regulators of cancer. However, their functional importance has often been …

Lung metastasis is the major cause of breast cancer-related mortality. The neutrophil-
associated inflammatory microenvironment aids tumor cells in metastatic colonization in …

Wnt signaling is a highly conserved signaling pathway that plays a critical role in controlling
embryonic and organ development, as well as cancer progression. Genome-wide …

Although substantial progress has been made in cancer biology and treatment, clinical
outcomes of bladder carcinoma (BC) patients are still not satisfactory. The tumor …

Metastasis causes breast cancer-related mortality. Tumor-infiltrating neutrophils (TINs) inflict
immunosuppression and promote metastasis. Therapeutic debilitation of TINs may enhance …

Background Immunotherapy has recently emerged as a treatment strategy which stimulates
the human immune system to kill tumor cells. Tumor immunotherapy is based on immune …

Triple-negative breast cancer (TNBC) is an aggressive subtype characterized by extensive
intra-tumoral heterogeneity, and frequently develops resistance to therapies. Tumor …