Hydroxyl radical protein footprinting (HRPF) coupled to mass spectrometry has been
successfully used to investigate a plethora of protein-related questions. The method, which …

Biotherapeutics are increasingly becoming the mainstay in the treatment of a variety of
human conditions, particularly in oncology and hematology. The production of therapeutic …

Scope Synonymous codon usage has been a focus of investigation since the discovery of
the genetic code and its redundancy. The occurrences of synonymous codons vary between …

Chemokines drive cell migration through their interactions with seven-transmembrane (7TM)
chemokine receptors on cell surfaces. The atypical chemokine receptor 3 (ACKR3) binds …

Hydroxyl radical protein footprinting (HRPF) in combination with mass spectrometry reveals
the relative solvent exposure of labeled residues within a protein, thereby providing insight …

Hydroxyl radical protein footprinting (HRPF) is a powerful and flexible technique for probing
changes in protein topography. With the development of the fast photochemical oxidation of …

In recent years mass spectrometry-based covalent labeling techniques such as hydroxyl
radical footprinting (HRF) have emerged as valuable structural biology techniques, yielding …

Human estrogen receptor alpha (hERα) is a hormone-responsive nuclear receptor (NR)
involved in cell growth and survival that contains both a DNA-binding domain (DBD) and a …

Hydroxyl radical footprinting (HRF) of proteins with mass spectrometry (MS) is a widespread
approach for assessing protein structure. Hydroxyl radicals react with a wide variety of …

Structural biology is entering an exciting time where many new high-resolution structures of
large complexes and membrane proteins are determined regularly. These advances have …