Kidney involvement in patients with systemic lupus erythematosus—lupus nephritis (LN)—is
one of the most important and common clinical manifestations of this disease and occurs in …

Dysregulation of auto-reactive T cells and autoantibody-producing B cells and excessive
inflammation are responsible for the occurrence and development of autoimmune diseases …

Monogenic lupus, a distinctive variant of systemic lupus erythematosus (SLE), is
characterized by early onset, family-centric clustering, and heightened disease severity. So …

Sensing of microbes or of danger signals has mainly been attributed to myeloid innate
immune cells. However, T and B cells also express functional pattern recognition receptors …

Autoimmune diseases are characterized by vast alterations in immune responses, but the
pathogenesis remains sophisticated and yet to be fully elucidated. Multiple mechanisms …

Introduction: Several environmental stimuli may influence lupus, particularly viral infections.
In this study, we used an imiquimod-induced lupus mouse model focused on the TLR7 …

Activated B cells experience metabolic changes that require mitochondrial remodeling, in a
process incompletely defined. In this study, we report that mitochondrial antiviral signaling …

Significance: Numerous abnormalities in T cells have been described in patients with
systemic lupus erythematosus (SLE), including lymphopenia, DNA demethylation …

Women have been at the forefront of tremendous achievements in immunology in the past
decade. However, disparities still exist, limiting upward potential and further advancements …

Bien que les cellules B et leur rôle dans l'immunité humorale soient essentiels à la défense
immunitaire contre de nombreuses infections, au cours de certaines maladies, les cellules B …