Chronic obstructive pulmonary diseases (COPD), comprised of pulmonary emphysema,
chronic bronchitis, and structural and inflammatory changes of small airways, is a leading …

The European Respiratory Society (ERS) Research Seminar entitled “Pulmonary vascular
endothelium: orchestra conductor in respiratory diseases-highlights from basic research to …

DNA‐encoded chemical library technology was developed with the vision of its becoming a
transformational platform for drug discovery. The hope was that a new paradigm for the …

Alterations in pulmonary vessel structure and function are highly prevalent in patients with
COPD. Vascular abnormalities impair gas exchange and may result in pulmonary …

The secondary role of pathology in the present clinical management of pulmonary
hypertension (PH) reflects to some extent the limitations of the current understanding of the …

Pulmonary hypertension (PH) because of chronic lung disease is categorized as Group 3
PH in the most recent classification system. Prevalence of these diseases is increasing over …

Rationale: Severe pulmonary arterial hypertension (PAH) is characterized by the formation
of plexiform lesions and concentric intimal fibrosis in small pulmonary arteries. The origin of …

Recent studies demonstrate that sustained hypoxia induces the robust accumulation of
leukocytes and mesenchymal progenitor cells in pulmonary arteries (PAs). Since the factors …

Rationale: Basic research implicates alveolar endothelial cell apoptosis in the pathogenesis
of chronic obstructive pulmonary disease (COPD) and emphysema. However, information …

Cardiovascular disease represents a considerable burden in terms of both morbidity and
mortality in patients with chronic obstructive pulmonary disease (COPD). For 20 years …