The superfamily of phospholipase A2 (PLA2) enzymes currently consists of 15 Groups and
many subgroups and includes five distinct types of enzymes, namely the secreted PLA2s …

Conspectus Biomolecules such as peptides, proteins, and nucleic acids generally cannot
cross a cell membrane by passive diffusion. Nevertheless, cell-penetrating peptides (CPPs) …

Adeno-associated virus (AAV) based vectors have emerged as important tools for gene
therapy in humans. The recent successes seen in Phase I/II clinical trials have also …

In order to replicate, most pathogens need to enter their target cells. Many viruses enter the
host cell through an endocytic pathway and hijack endosomes for their journey towards sites …

Common features of parvovirus capsids are open pores at the fivefold symmetry axes that
traverse the virion shell. Upon limited heat treatment in vitro, the pores can function as …

The importance of the phospholipase A2 domain located within the unique N terminus of the
capsid viral protein VP1 (VP1u) in parvovirus infection has been reported. This study used …

Phospholipids are present in all living organisms. They are a major component of all
biological membranes, along with glycolipids and cholesterol. Enzymes aimed at modifying …

Adeno-associated virus type 2 (AAV2) capsids show 12 pores at the fivefold axes of
symmetry. We mutated amino acids which constitute these pores to investigate possible …

Parvoviruses are small, rugged, nonenveloped protein particles containing a linear,
nonpermuted, single-stranded DNA genome of∼ 5 kb. Their limited coding potential …

The complex infection process of parvoviruses is not well understood so far. An important
role has been attributed to a phospholipase A2 domain which is located within the unique N …