An individualized innovative disease management is of great importance for people with
multiple sclerosis (pwMS) to cope with the complexity of this chronic, multidimensional …

Multiple sclerosis (MS) is the inflammatory demyelinating and neurodegenerative disease of
the central nervous system (CNS) that affects approximately 2.8 million people worldwide. In …

Microglia, besides being able to react rapidly to a wide range of environmental changes, are
also involved in shaping neuronal wiring. Indeed, they actively participate in the modulation …

Multiple sclerosis (MS) as a chronic inflammatory disorder of the central nervous system
(CNS) is thought to be caused by the abnormal induction of immune responses …

Multiple sclerosis (MS) is an inflammatory demyelinating and degenerative disease of the
central nervous system (CNS). Although inflammatory responses are efficiently treated …

Despite significant advances in our understanding of the pathophysiology of multiple
sclerosis (MS), knowledge about contribution of individual ion channels to axonal …

Background: MiR-146a is an important regulator of innate inflammatory responses and is
also implicated in cell death and survival. Methods: By sorting CNS resident cells, microglia …

Background Inhibition of Bruton's tyrosine kinase (BTK) is an emerging multiple sclerosis
(MS) therapy. BTK inhibitors (BTKi) cross the blood-brain barrier and modulate B cells and …

To identify markers in the CSF of multiple sclerosis (MS) subtypes, we used a two-step
proteomic approach:(i) Discovery proteomics compared 169 pooled CSF from MS subtypes …

Background Trigeminal neuralgia (TN) is a severe type of facial pain. A neurovascular
conflict between cranial nerve V and a nearby vessel is the main pathophysiological …