R loops are nucleic acid structures composed of an RNA–DNA hybrid and a displaced
single-stranded DNA. Recently, evidence has emerged that R loops occur more often in the …

Satellite DNA represents one of the most fascinating parts of the repetitive fraction of the
eukaryotic genome. Since the discovery of highly repetitive tandem DNA in the 1960s, a lot …

Maintenance of a minimal telomere length is essential to prevent cellular senescence. When
critically short telomeres arise in the absence of telomerase, they can be repaired by …

Genome replication involves dealing with obstacles that can result from DNA damage but
also from chromatin alterations, topological stress, tightly bound proteins or non-B DNA …

RNA: DNA hybrid structures known as R loops were thought to be rare byproducts of
transcription. In the last decade, however, accumulating evidence has pointed to a new view …

The natural ends of linear chromosomes require unique genetic and structural adaptations
to facilitate the protection of genetic material. This is achieved by the sequestration of the …

From the earliest comparisons of RNA production with steady-state levels, it has been clear
that cells transcribe more RNA than they accumulate, implying the existence of active RNA …

The XRN family of 5′→ 3′ exoribonucleases is critical for ensuring the fidelity of cellular
RNA turnover in eukaryotes. Highly conserved across species, the family is typically …

The intriguing structural diversity in folded topologies available to guanine-rich nucleic acid
repeat sequences have made four-stranded G-quadruplex structures the focus of both basic …

All RNA species in yeast cells are subject to turnover. Work over the past 20 years has
defined degradation mechanisms for messenger RNAs, transfer RNAs, ribosomal RNAs …