The advent of sulfur (vi)-fluoride exchange (SuFEx) processes as transformations with click-
like reactivity has invigorated research into electrophilic species featuring a sulfur–fluorine …

SuFEx (Sulfur Fluoride Exchange) is a modular, next generation family of click reactions,
geared towards the rapid and reliable assembly of functional molecules. This review …

Bioorthogonal chemistries enable researchers to interrogate biomolecules in living systems.
These reactions are highly selective and biocompatible, and can be performed in many …

Interactions among biomacromolecules, predominantly noncovalent, underpin biological
processes. However, recent advancements in biospecific chemistry have enabled the …

Protein–carbohydrate interactions play important roles in various biological processes, such
as organism development, cancer metastasis, pathogen infection and immune response, but …

Crosslinking of proteins has gained immense significance in the fabrication of biomaterials
for various health care applications. Various novel chemical-based strategies are being …

Sulfur fluoride exchange (SuFEx) has emerged as the new generation of click chemistry. We
report here a SuFEx-enabled, agnostic approach for the discovery and optimization of …

Crosslinking mass spectrometry (crosslinking-MS) is a versatile tool providing structural
insights into protein conformation and protein-protein interactions. Its medium-resolution …

Optimization of small-molecule probes or drugs is a synthetically lengthy, challenging, and
resource-intensive process. Lack of automation and reliance on skilled medicinal chemists …

Covalent probes serve as valuable tools for global investigation of protein function and
ligand binding capacity. Despite efforts to expand coverage of residues available for …