Melanoma represents the most aggressive and the deadliest form of skin cancer. Current
therapeutic approaches include surgical resection, chemotherapy, photodynamic therapy …

The recent developments in immuno-oncology have opened an unprecedented avenue for
the emergence of vaccine strategies. Therapeutic DNA cancer vaccines are now considered …

Cutaneous melanoma is the most common skin cancer with an incidence that has been
rapidly increasing in the past decades. Melanomas are among the most immunogenic …

Purpose Vitiligo-like depigmentation in patients with melanoma may be associated with
more favorable clinical outcome. We conducted a systematic review of patients with stage III …

Faced with the challenges posed by infectious diseases and cancer, nucleic acid vaccines
present excellent prospects in clinical applications. Compared with traditional vaccines …

Although T cell memory is generally thought to require direct antigen exposure, we found an
abundance of memory-phenotype cells (20%–90%, averaging over 50%) of CD4+ T cells …

DNA vaccination has emerged as an attractive immunotherapeutic approach against cancer
due to its simplicity, stability, and safety. Results from numerous clinical trials have …

Ipilimumab, a monoclonal antibody against cytotoxic T lymphocyte antigen 4 (CTLA-4), has
been shown to improve survival in patients with advanced metastatic melanoma. It also …

Objective—To evaluate the safety and efficacy of a vaccine containing plasmid DNA with an
insert encoding human tyrosinase (ie, huTyr vaccine) as adjunctive treatment for oral …

Melanoma is a relentless type of skin cancer which involves myriad signaling pathways
which regulate many cellular processes. This makes melanoma difficult to treat, especially …