Natural and synthetic glucocorticoids (GCs) are widely employed in a number of
inflammatory, autoimmune and neoplastic diseases, and, despite the introduction of novel …

This systematic review and meta-analysis compared the efficacy and toxicity of
dexamethasone (DEX) versus prednisone (PRED) for induction therapy in childhood acute …

Personalized medicine is focused on research disciplines which contribute to the
individualization of therapy, like pharmacogenomics and pharmacotranscriptomics. Acute …

Abstract Background Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a
debilitating idiopathic disease characterized by unexplained fatigue that fails to resolve with …

Acute lymphoblastic leukemia (ALL) is a relatively rare disease in adults accounting for no
more than 20% of all cases of acute leukemia. By contrast with the pediatric population, in …

Acute lymphoblastic leukemia (ALL) is the major pediatric cancer in developed countries.
Although treatment outcome has improved owing to advances in chemotherapy, there is still …

Glucocorticoids (GCs) are widely used for treating asthma, rheumatoid arthritis, nephrotic
syndrome, acute lymphoblastic leukemia and other autoimmune diseases. However, in a …

Objective: Glucocorticoids (GCs) are the key drugs for the treatment of pediatric acute
lymphoblastic leukemia (ALL). Herein, investigation of the relationship between the N363S …

Despite major advances in the management and high cure rates of childhood acute
lymphoblastic leukemia (ALL), patients still suffer from many drug-induced toxicities …

Drug-related toxicities represent an important clinical concern in chemotherapy, genetic
variants could help tailoring treatment to patient. A pharmacogenetic multicentric study was …