Viral membrane fusion: a dance between proteins and lipids

JM White, AE Ward, L Odongo… - Annual review of …, 2023 - annualreviews.org
There are at least 21 families of enveloped viruses that infect mammals, and many contain
members of high concern for global human health. All enveloped viruses have a dedicated …

Serinc5 restricts HIV membrane fusion by altering lipid order and heterogeneity in the viral membrane

AE Ward, D Sokovikova, MN Waxham… - ACS infectious …, 2023 - ACS Publications
The host restriction factor, Serinc5, incorporates into budding HIV particles and inhibits their
infection by an incompletely understood mechanism. We have previously reported that …

Restriction of influenza A virus by SERINC5

KK Lai, JB Munro, G Shi, S Majdoul, AA Compton… - Mbio, 2022 - Am Soc Microbiol
ABSTRACT Serine incorporator 5 (Ser5), a transmembrane protein, has recently been
identified as a host antiviral factor against human immunodeficiency virus (HIV)-1 and …

SERINC5-mediated restriction of HIV-1 infectivity correlates with resistance to cholesterol extraction but not with lipid order of viral membrane

G Raghunath, YC Chen, M Marin, H Wu, GB Melikyan - Viruses, 2022 - mdpi.com
Serine incorporator 5 (SER5) is a protein that upon incorporation into virions inhibits HIV-1
infectivity by interfering with the ability of the Env glycoprotein to promote viral fusion. The …