Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system and
common cause of non-traumatic neurological disability in young adults. The likelihood for an …

Abstract Type 1 diabetes (T1D) results from the autoimmune destruction of insulin-producing
beta cells in the pancreas. Prevention of T1D will require the ability to detect and modulate …

The physiological functions of natural killer (NK) cells in human immunity and reproduction
depend upon diverse interactions between killer cell immunoglobulin-like receptors (KIRs) …

In all human cells, human leukocyte antigen (HLA) class I glycoproteins assemble with a
peptide and take it to the cell surface for surveillance by lymphocytes. These include natural …

Interactions between HLA class I molecules and killer-cell immunoglobulin-like receptors
(KIR) control natural killer cell (NK) functions in immunity and reproduction. Encoded by …

Killer‐cell immunoglobulin‐like receptors (KIR s) are components of two fundamental
biological systems essential for human health and survival. First, they contribute to host …

Genes encoding antigen‐presenting molecules within the human major histocompatibility
complex (MHC) account for the highest component of genetic risk for many neurological …

Interactions of killer cell immunoglobin-like receptors (KIR) with human leukocyte antigens
(HLA) class I regulate effector functions of key cytotoxic cells of innate and adaptive …

Shaping natural killer (NK) cell functions in human immunity and reproduction are diverse
killer cell immunoglobulin‐like receptors (KIR s) that recognize polymorphic MHC class I …

Large population studies of immune system genes are essential for characterizing their role
in diseases, including autoimmune conditions. Of key interest are a group of genes …