High‐grade brain tumors are heterogeneous with respect to the composition of bona fide
tumor cells and with respect to a range of intermingling parenchymal cells. Glioblastomas …

Simple Summary Glioblastoma is one of the most treatment-refractory human malignancies,
and despite techniques that have allowed scientists and clinicians to better understand the …

Microglia, which contribute substantially to the tumor mass of glioblastoma, have been
shown to play an important role in glioma growth and invasion. While a large number of …

JAK-STAT is an efficient and highly regulated system mainly dedicated to the regulation of
gene expression. Primarily identified as functioning in hematopoietic cells, its role has been …

Proteins of the signal transducer and activator of transcription (STAT) family mediate cellular
responses to cytokines and growth factors. Aberrant regulation of the STAT3 oncogene …

Background Signal transducer and activator of transcription 3 (STAT3) is persistently
activated in squamous cell carcinoma of the head and neck (SCCHN) and can cause …

Signal transducer and activator of transcription 3 (STAT3) regulates many critical functions in
human normal and malignant tissues, such as differentiation, proliferation, survival …

BACKGROUND & AIMS: Recently, we reported that sorafenib sensitizes hepatocellular
carcinoma (HCC) cells to TRAIL through the inhibition of signal transducer and activator of …

Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor in
adults. Despite intensive treatment, the prognosis for patients with GBM remains grim with a …

Glioblastoma multiforme (GBM) is the most aggressive form of cancer that begins within the
brain; generally, the patient has a dismal prognosis and limited therapeutic options. Signal …