Protein–protein interactions (PPIs) are involved at all levels of cellular organization, thus
making the development of PPI inhibitors extremely valuable. The identification of selective …

The human immunodeficiency virus (HIV) genome encodes a total of three structural
proteins, two envelope proteins, three enzymes, and six accessory proteins. Studies over the …

Immature HIV-1 assembles at and buds from the plasma membrane before proteolytic
cleavage of the viral Gag polyprotein induces structural maturation. Maturation can be …

Nuclear entry of HIV-1 replication complexes through intact nuclear pore complexes is
critical for successful infection. The host protein cleavage-and-polyadenylation-specificity …

The Gag proteins of HIV-1, like those of other retroviruses, are necessary and sufficient for
the assembly of virus-like particles. The roles played by HIV-1 Gag proteins during the life …

HIV protease plays a crucial role in the viral life cycle and is essential for the generation of
mature infectious virus particles. Detailed knowledge of the structure of HIV protease and its …

HIV-1 assembly occurs at the inner leaflet of the plasma membrane (PM) in highly ordered
membrane microdomains. The size and stability of membrane microdomains is regulated by …

The human immunodeficiency virus type 1 initially assembles and buds as an immature
particle that is organized by the viral Gag polyprotein. Gag is then proteolyzed to produce …

Gag, the primary structural protein of HIV-1, is recruited to the plasma membrane for virus
assembly by its matrix (MA) domain. Gag is subsequently cleaved into its component …

The retroviral protease of human immunodeficiency virus (HIV) is an excellent target for
antiviral inhibitors for treating HIV/AIDS. Despite the efficacy of therapy, current efforts to …