The emerging importance of IgG Fab glycosylation in immunity
FS van de Bovenkamp, L Hafkenscheid… - The Journal of …, 2016 - journals.aai.org
Human IgG is the most abundant glycoprotein in serum and is crucial for protective
immunity. In addition to conserved IgG Fc glycans,∼ 15–25% of serum IgG contains glycans …
immunity. In addition to conserved IgG Fc glycans,∼ 15–25% of serum IgG contains glycans …
Follicular lymphoma: evolving therapeutic strategies
BS Kahl, DT Yang - Blood, The Journal of the American Society …, 2016 - ashpublications.org
Follicular lymphoma (FL) is the most common indolent non-Hodgkin lymphoma in the
Western hemisphere. After decades of stagnation, the natural history of FL appears to have …
Western hemisphere. After decades of stagnation, the natural history of FL appears to have …
Oral mucosal breaks trigger anti-citrullinated bacterial and human protein antibody responses in rheumatoid arthritis
Periodontal disease is more common in individuals with rheumatoid arthritis (RA) who have
detectable anti-citrullinated protein antibodies (ACPAs), implicating oral mucosal …
detectable anti-citrullinated protein antibodies (ACPAs), implicating oral mucosal …
Surface Ig variable domain glycosylation affects autoantigen binding and acts as threshold for human autoreactive B cell activation
T Kissel, C Ge, L Hafkenscheid, JC Kwekkeboom… - Science …, 2022 - science.org
The hallmark autoantibodies in rheumatoid arthritis are characterized by variable domain
glycans (VDGs). Their abundant occurrence results from the selective introduction of N …
glycans (VDGs). Their abundant occurrence results from the selective introduction of N …
Insights into the microbiome of breast implants and periprosthetic tissue in breast implant-associated anaplastic large cell lymphoma
Though rare, breast implant-associated anaplastic large cell lymphoma (BIA-ALCL), a
CD30+ T-cell lymphoma associated with textured breast implants, has adversely impacted …
CD30+ T-cell lymphoma associated with textured breast implants, has adversely impacted …
Adaptive antibody diversification through N-linked glycosylation of the immunoglobulin variable region
FS Van De Bovenkamp, NIL Derksen… - Proceedings of the …, 2018 - National Acad Sciences
A hallmark of B-cell immunity is the generation of a diverse repertoire of antibodies from a
limited set of germline V (D) J genes. This repertoire is usually defined in terms of amino …
limited set of germline V (D) J genes. This repertoire is usually defined in terms of amino …
DC-SIGN–expressing macrophages trigger activation of mannosylated IgM B-cell receptor in follicular lymphoma
Follicular lymphoma (FL) results from the accumulation of malignant germinal center (GC) B
cells leading to the development of an indolent and largely incurable disease. FL cells …
cells leading to the development of an indolent and largely incurable disease. FL cells …
The role of antibody glycosylation in autoimmune and alloimmune kidney diseases
A Beyze, C Larroque, M Le Quintrec - Nature Reviews Nephrology, 2024 - nature.com
Immunoglobulin glycosylation is a pivotal mechanism that drives the diversification of
antibody functions. The composition of the IgG glycome is influenced by environmental …
antibody functions. The composition of the IgG glycome is influenced by environmental …
Lectin binding to surface Ig variable regions provides a universal persistent activating signal for follicular lymphoma cells
The vast majority of cases of follicular lymphoma (FL), but not normal B cells, acquire N-
glycosylation sites in the immunoglobulin variable regions during somatic hypermutation …
glycosylation sites in the immunoglobulin variable regions during somatic hypermutation …
Protein glycosylation investigated by mass spectrometry: an overview
The protein glycosylation is a post-translational modification of crucial importance for its
involvement in molecular recognition, protein trafficking, regulation, and inflammation …
involvement in molecular recognition, protein trafficking, regulation, and inflammation …