Polygenic scores to assess atherosclerotic cardiovascular disease risk: clinical perspectives and basic implications
KG Aragam, P Natarajan - Circulation research, 2020 - Am Heart Assoc
An individual's susceptibility to atherosclerotic cardiovascular disease is influenced by
numerous clinical and lifestyle factors, motivating the multifaceted approaches currently …
numerous clinical and lifestyle factors, motivating the multifaceted approaches currently …
How to develop, validate, and compare clinical prediction models involving radiological parameters: study design and statistical methods
Clinical prediction models are developed to calculate estimates of the probability of the
presence/occurrence or future course of a particular prognostic or diagnostic outcome from …
presence/occurrence or future course of a particular prognostic or diagnostic outcome from …
Detection and prognostic value of pulmonary congestion by lung ultrasound in ambulatory heart failure patients
Aims Pulmonary congestion is a common and important finding in heart failure (HF). While
clinical examination and chest radiography are insensitive, lung ultrasound (LUS) is a novel …
clinical examination and chest radiography are insensitive, lung ultrasound (LUS) is a novel …
A unified inference procedure for a class of measures to assess improvement in risk prediction systems with survival data
Risk prediction procedures can be quite useful for the patient's treatment selection,
prevention strategy, or disease management in evidence‐based medicine. Often, potentially …
prevention strategy, or disease management in evidence‐based medicine. Often, potentially …
Quantifying the added value of new biomarkers: how and how not
NR Cook - Diagnostic and Prognostic Research, 2018 - Springer
Over the past few decades, interest in biomarkers to enhance predictive modeling has
soared. Methodology for evaluating these has also been an active area of research. There …
soared. Methodology for evaluating these has also been an active area of research. There …
MicroRNA signatures differentiate preserved from reduced ejection fraction heart failure
Aims Differentiation of heart failure with reduced (HFrEF) or preserved (HFpEF) ejection
fraction independent of echocardiography is challenging in the community. Diagnostic …
fraction independent of echocardiography is challenging in the community. Diagnostic …
The net reclassification index (NRI): a misleading measure of prediction improvement even with independent test data sets
Abstract The Net Reclassification Index (NRI) is a very popular measure for evaluating the
improvement in prediction performance gained by adding a marker to a set of baseline …
improvement in prediction performance gained by adding a marker to a set of baseline …
Testing for improvement in prediction model performance
MS Pepe, KF Kerr, G Longton, Z Wang - Statistics in medicine, 2013 - Wiley Online Library
Authors have proposed new methodology in recent years for evaluating the improvement in
prediction performance gained by adding a new predictor, Y, to a risk model containing a set …
prediction performance gained by adding a new predictor, Y, to a risk model containing a set …
A note on the evaluation of novel biomarkers: do not rely on integrated discrimination improvement and net reclassification index
J Hilden, TA Gerds - Statistics in medicine, 2014 - Wiley Online Library
The 'integrated discrimination improvement'(IDI) and the 'net reclassification index'(NRI) are
statistics proposed as measures of the incremental prognostic impact that a new biomarker …
statistics proposed as measures of the incremental prognostic impact that a new biomarker …
Performance metrics for the comparative analysis of clinical risk prediction models employing machine learning
Background: New methods such as machine learning techniques have been increasingly
used to enhance the performance of risk predictions for clinical decision-making. However …
used to enhance the performance of risk predictions for clinical decision-making. However …