In experimental evolution, laboratory-controlled conditions select for the adaptation of
species, which can be monitored in real time. Despite the current popularity of such …

Microbial experimental evolution uses controlled laboratory populations to study the
mechanisms of evolution. The molecular analysis of evolved populations enables empirical …

Horizontal gene transfer (HGT) confers the rapid acquisition of novel traits and is pervasive
throughout microbial evolution. Despite the central role of HGT, the evolutionary forces that …

Horizontal gene transfer (HGT) is important for microbial evolution, yet we know little about
the fitness effects and dynamics of horizontally transferred genetic variants. In this study, we …

Since antibiotic development lags, we search for potential drug targets through directed
evolution experiments. A challenge is that many resistance genes hide in a noisy mutational …

Evolutionary dynamics is often viewed as a subtle process of change accumulation that
causes a divergence among organisms and their genomes. However, this interpretation is …

Adaptive laboratory evolution (ALE) has long been used as the tool of choice for microbial
engineering applications, ranging from the production of commodity chemicals to the …

Conventional 20th century evolution thinking was based on the idea of isolated genomes for
each species. Any possibility of life‐history inputs to the germ line was strictly excluded by …

All organisms encode enzymes that replicate, maintain, pack, recombine, and repair their
genetic material. For this reason, mutation rates and biases also evolve by mutation …

Adaptive laboratory evolution (ALE) is used to find causal mutations that underlie improved
strain performance under the applied selection pressure. ALE studies have revealed that …