EGFR signaling pathway as therapeutic target in human cancers
Abstract Epidermal Growth Factor Receptor (EGFR) enacts major roles in the maintenance
of epithelial tissues. However, when EGFR signaling is altered, it becomes the grand …
of epithelial tissues. However, when EGFR signaling is altered, it becomes the grand …
Mechanisms of receptor tyrosine kinase activation in cancer
Receptor tyrosine kinases (RTKs) play an important role in a variety of cellular processes
including growth, motility, differentiation, and metabolism. As such, dysregulation of RTK …
including growth, motility, differentiation, and metabolism. As such, dysregulation of RTK …
Targeting cartilage EGFR pathway for osteoarthritis treatment
Osteoarthritis (OA) is a widespread joint disease for which there are no disease-modifying
treatments. Previously, we found that mice with cartilage-specific epidermal growth factor …
treatments. Previously, we found that mice with cartilage-specific epidermal growth factor …
Inhibition of RAS function through targeting an allosteric regulatory site
RAS GTPases are important mediators of oncogenesis in humans. However,
pharmacological inhibition of RAS has proved challenging. Here we describe a functionally …
pharmacological inhibition of RAS has proved challenging. Here we describe a functionally …
Endocytosis and cancer
I Mellman, Y Yarden - Cold Spring Harbor perspectives …, 2013 - cshperspectives.cshlp.org
Endocytosis entails selective packaging of cell-surface proteins, such as receptors for
cytokines and adhesion components, in cytoplasmic vesicles (endosomes). The series of …
cytokines and adhesion components, in cytoplasmic vesicles (endosomes). The series of …
A structural perspective on the regulation of the epidermal growth factor receptor
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that plays a
critical role in the pathogenesis of many cancers. The structure of intact forms of this receptor …
critical role in the pathogenesis of many cancers. The structure of intact forms of this receptor …
Integrated genomic characterization reveals novel, therapeutically relevant drug targets in FGFR and EGFR pathways in sporadic intrahepatic cholangiocarcinoma
MJ Borad, MD Champion, JB Egan, WS Liang… - PLoS …, 2014 - journals.plos.org
Advanced cholangiocarcinoma continues to harbor a difficult prognosis and therapeutic
options have been limited. During the course of a clinical trial of whole genomic sequencing …
options have been limited. During the course of a clinical trial of whole genomic sequencing …
Tyrosine phosphorylation: thirty years and counting
T Hunter - Current opinion in cell biology, 2009 - Elsevier
In the 30 years since its discovery, tyrosine phosphorylation has emerged as a
fundamentally important mechanism of signal transduction and regulation in all eukaryotic …
fundamentally important mechanism of signal transduction and regulation in all eukaryotic …
The structural basis of ligand perception and signal activation by receptor kinases
Plants have evolved a family of unique membrane receptor kinases to orchestrate the
growth and development of their cells, tissues, and organs. Receptor kinases also form the …
growth and development of their cells, tissues, and organs. Receptor kinases also form the …
Raf family kinases: old dogs have learned new tricks
D Matallanas, M Birtwistle, D Romano… - Genes & …, 2011 - journals.sagepub.com
First identified in the early 1980s as retroviral oncogenes, the Raf proteins have been the
objects of intense research. The discoveries 10 years later that the Raf family members (Raf …
objects of intense research. The discoveries 10 years later that the Raf family members (Raf …