Zoonotic potential of influenza A viruses: a comprehensive overview
Influenza A viruses (IAVs) possess a great zoonotic potential as they are able to infect
different avian and mammalian animal hosts, from which they can be transmitted to humans …
different avian and mammalian animal hosts, from which they can be transmitted to humans …
Interferon lambda: modulating immunity in infectious diseases
M Syedbasha, A Egli - Frontiers in immunology, 2017 - frontiersin.org
Interferon lambdas (IFN-λs; IFNL1-4) modulate immunity in the context of infections and
autoimmune diseases, through a network of induced genes. IFN-λs act by binding to the …
autoimmune diseases, through a network of induced genes. IFN-λs act by binding to the …
The NS1 protein: a multitasking virulence factor
J Ayllon, A García-Sastre - Influenza Pathogenesis and Control-Volume II, 2014 - Springer
The non-structural protein 1 of influenza virus (NS1) is a relatively small polypeptide with an
outstanding number of ascribed functions. NS1 is the main viral antagonist of the innate …
outstanding number of ascribed functions. NS1 is the main viral antagonist of the innate …
The impact of the interferon-lambda family on the innate and adaptive immune response to viral infections
Type-III interferons (IFN-λ, IFNL) are the most recently described family of IFNs. This family of
innate cytokines are increasingly being ascribed pivotal roles in host–pathogen interactions …
innate cytokines are increasingly being ascribed pivotal roles in host–pathogen interactions …
NS1: a Key protein in the “game” between influenza A virus and host in innate immunity
Z Ji, X Wang, X Liu - Frontiers in cellular and infection microbiology, 2021 - frontiersin.org
Since the influenza pandemic occurred in 1918, people have recognized the perniciousness
of this virus. It can cause mild to severe infections in animals and humans worldwide, with …
of this virus. It can cause mild to severe infections in animals and humans worldwide, with …
Fitness determinants of influenza A viruses
EF Griffin, SM Tompkins - Viruses, 2023 - mdpi.com
Influenza A (IAV) is a major human respiratory pathogen that causes illness,
hospitalizations, and mortality annually worldwide. IAV is also a zoonotic pathogen with a …
hospitalizations, and mortality annually worldwide. IAV is also a zoonotic pathogen with a …
Genetic characterization and pathogenesis of the first H9N2 low pathogenic avian influenza viruses isolated from chickens in Kenyan live bird markets
Poultry production plays an important role in the economy and livelihoods of rural
households in Kenya. As part of a surveillance program, avian influenza virus (AIV)-specific …
households in Kenya. As part of a surveillance program, avian influenza virus (AIV)-specific …
Specificity and functional interplay between influenza virus PA-X and NS1 shutoff activity
C Chaimayo, M Dunagan, T Hayashi, N Santoso… - PLoS …, 2018 - journals.plos.org
Influenza A viruses modulate host antiviral responses to promote viral growth and
pathogenicity. Through viral PA-X and NS1 proteins, the virus is capable of suppressing host …
pathogenicity. Through viral PA-X and NS1 proteins, the virus is capable of suppressing host …
A single amino acid substitution in the novel H7N9 influenza A virus NS1 protein increases CPSF30 binding and virulence
J Ayllon, P Domingues, R Rajsbaum, L Miorin… - Journal of …, 2014 - Am Soc Microbiol
Although an effective interferon antagonist in human and avian cells, the novel H7N9
influenza virus NS1 protein is defective at inhibiting CPSF30. An I106M substitution in H7N9 …
influenza virus NS1 protein is defective at inhibiting CPSF30. An I106M substitution in H7N9 …
The influenza NS1 protein modulates RIG-I activation via a strain-specific direct interaction with the second CARD of RIG-I
A critical role of influenza A virus nonstructural protein 1 (NS1) is to antagonize the host
cellular antiviral response. NS1 accomplishes this role through numerous interactions with …
cellular antiviral response. NS1 accomplishes this role through numerous interactions with …